ترجمه خبر (4)

ساخت نانوداروی ترمیم‌کننده زخم‌ها از عصاره‌ زردچوبه در کشور (ترجمه انگلیسی خبر)

 

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Iran's scientists use turmeric to develop nano-medicine for wound treatment

Tehran - Scientists developed an anti-inffective drug delivery system from turmeric extract and natural polymers that has proven useful in killing bacteria and treating wounds in an abrupt fashion. 

Infection is among the most critical contributing factors in mortality and disability, said Dr. Mirza Ali Mofzal Jahromi, a medical immunology specialist from Tarbiat-e-Modarres University, who was involved in the research.  Although antibiotics are prescribed frequently to treat different infections, they produce adverse side affects, and their intake results in drug resistance after a while. Meanwhile, they fail to restore injured textures.

He stressed the importance attached to the treatment of infections especially those inflicted upon military forces who have to frequently work in poorly equipped contexts, adding  it is inevitable to produce a nano-medicine preserved under extreme conditions in order to treat wounded soldiers. The study aimed to develop a harmless, effective nano-drug system to smartly release curcumin in infected targets. 

He went on to say that curcumin is a yellowish anti-microbial compound extracted from turmeric.  Chitosan is also a natural, biodegradable, biofriendly, low-toxic polymer used to produce nano-sized carriers for drug delivery, he added.  The study suggested chitosan/tripolyphosphate nanoparticles (CS/TPP) carrying curcumin can effectively treat infections arising from Staphylococcus aureus and Pseudomonas aeruginosa.

He added, "Results indicated that nanoparticles carrying curcumin significantly inhibit Staphylococcus aureus and Pseudomonas aeruginosa in infected mice."  

" This nano medical system is customized to inhibit bacteria in-vitro in a fashion that there is no sign of drug resistance."  Amazingly, this nano-drug can abruptly treat injuries too. Additionally, its production and preservation are not costly.

Curcumin is highly sensitive to light,  he said, when asked about the reason why chitosan was selected as the drug carrier. The polymeric nano-carrier prevents light from approaching the drug, so its medical properties remain intact. Additionally, nanoparticles cause gradual release of drug into the injured texture, so its inhibitory impact is fostered. Chitosan, itself, has anti microbial properties promoting medical effects of curcumin.

He also said, "Results indicated that the proposed nano-drug can successfully replace current antibiotics."

In conclusion, he said, "To optimally load curcumin (2±75%) on chitosan nanoparticles, ion-activated gelling with triphosphate was used in this study." "FTIR, AFM, SEM, TEM, and DLS tests and spectrometry were applied to assess physico-chemical properties of synthesized nano-carriers and the loaded drug quantity.

The study, which was published in the Iranian Journal of Biotechnology, was conducted by Dr. Mirza Ali Mofzal Jahromi, a medical immunology specialist from Tarbiat-e-Modarres University, and Dr. Reza Mirnejad and Dr. Mehdi Kamali, Baqiyatallah University of Medical Sciences faculty members.  

Translated by the blog's admin 

source:

ISNA 

(ساخت نانوداروی ترمیم‌کننده زخم‌ها از عصاره‌ زردچوبه در کشور)

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